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Why Cassava Sciences (SAVA) jumped over 30% today

  • Cassava Sciences jumps over 30% due to the new NIH grant of $2.5 million to support the ongoing clinical development of PTI-125 for the potential treatment of Alzheimer’s disease.
  • The company recently completed a Phase 2b trial in patients with mild-to-moderate Alzheimer’s disease.
  • Data on the trial should be available mid-year.
  • PTI-125 targets an altered form of filamin A, a scaffolding protein found throughout the body. A highly toxic form of the protein is present in the brains of AD sufferers which disrupts the normal function of neurons, leading to neurodegeneration and brain inflammation.
  • PTI-125 is made to restore the normal shape of filamin A in the brain, improving the function of multiple brain receptors and dampening neuroinflammation.

About Cassava Sciences

Cassava Sciences is a clinical-stage drug development company, develops drugs for nervous system disorders. The company’s lead therapeutic product candidate PTI-125, a small molecule drug that is in Phase II clinical trial for the treatment of Alzheimer’s disease.

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